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Aggressive Behavior Predictors in Solitary Fibrous Tumor: Demographic, Clinical, and Histopathologic Characteristics of 81 Cases

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Abstract

Background

Solitary fibrous tumor (SFT) is a rare mesenchymal tumor with an intermediate tendency to metastasize. Meningeal hemangiopericytoma (HPC), arising in the meningeal membranes, also is considered an SFT. Although SFT is assumed to show an unpredictable behavior, the authors defined some factors associated with its aggressive behavior.

Methods

This retrospective study was based on the medical records of 81 SFT patients treated surgically, with the median follow-up period of 59 months. The patients were assigned to three histopathologic groups based on the 2016 WHO classification: group 1 (SFT, 29 patients), group 2 (cellular SFT/hemangiopericytoma [HPC], 27 patients), and group 3 (malignant SFT/anaplastic HPC, 25 patients).

Results

The SFT histopathologic classification was associated with distant metastasis (DM) (p = 0.007). The multivariate analysis showed that cellular SFT had an independent impact on DM (odds ratio [OR] = 25.42; p = 0.006). Tumor diameter larger than 7.25 cm was correlated with DM (p = 0.010) and the patient’s disease-specific death (DSD) (p = 0.007). A 1-cm increase in tumor diameter enhanced the likelihood of metastasis by 1.26 (OR = 1.26; 95% confidence interval [CI], 1.05–1.53). Tumors originating from the central nervous system (CNS) showed a greater tendency toward local recurrence (LR) (p = 0.039) and DM (p = 0.05). Radiotherapy had no association with LR, DM, or DSD. The 10-year disease-specific survival rate was 82.7%.

Conclusions

Tumor size and histopathologic diagnosis are the predictors of SFT’s aggressive behavior. Cellular SFTs behave as aggressively as the malignant form of the tumor. A SFT grading based on SFT cellularity would contribute to anticipation of its aggressive behavior.

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Acknowledgment

We thank Dr. Leila Seddigh for her assistance in data analysis and Steven Salomon, MSc, for his assistance in collecting data and conducting this study.

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Authors and Affiliations

  1. Division of Orthopedic Surgery, McGill University Health Center, Montreal, Quebec, Canada

    Mohammad Hassani MD & Robert E. Turcotte MD, FRCSC

  2. Division of Orthopedic Surgery, Mashhad University of Medical Sciences, Mashhad, Iran

    Mohammad Hassani MD

  3. Department of Pathology, McGill University Health Center, Montreal, Quebec, Canada

    Sungmi Jung MD

  4. Division of Orthopedic Surgery, McGill University, Montreal, Quebec, Canada

    Livia Garzia PhD

  5. McGill University, Montreal, Canada

    Elaheh Ghodsi MD

  6. Department of Oncology, McGill University Health Center, Montreal, Quebec, Canada

    Thierry Alcindor MD, FRCPC

Authors
  1. Mohammad Hassani MD
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  2. Sungmi Jung MD
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  3. Livia Garzia PhD
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  4. Elaheh Ghodsi MD
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  5. Thierry Alcindor MD, FRCPC
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  6. Robert E. Turcotte MD, FRCSC
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Correspondence to Robert E. Turcotte MD, FRCSC.

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This study has been designed and accomplished at McGill University Health Center, Montreal, Quebec, Canada

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Hassani, M., Jung, S., Garzia, L. et al. Aggressive Behavior Predictors in Solitary Fibrous Tumor: Demographic, Clinical, and Histopathologic Characteristics of 81 Cases. Ann Surg Oncol 28, 6861–6867 (2021). https://doi.org/10.1245/s10434-021-09592-w

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  • DOI: https://doi.org/10.1245/s10434-021-09592-w

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